Scientists are One Step Closer to Reversing the Aging Process Entirely

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by PHILIP PERRY (bigthink.com)

Imagine a medication that could take years off of your looks.

I’m determined to age gracefully. Though my wife plucks every gray hair she finds, I’d be bald if I did. Even so, I’ve kept myself up over the years, prompting my college girlfriend, whom I recently reconnected with to exclaim, “You haven’t aged at all!” Except for more gray hair, that is. Perhaps it’s just good genes. I’ve always chalked it up to stress-free living. So what can be done to overcome the aging process? Creams, lotions, and other products fill pharmacy shelves, but few have a truly substantial impact.

Now, researchers at the Salk Institute in La Jolla, California have discovered a way to turn back the hands of time. Juan Carlos Izpisua Belmonte led this study, published in the journal Cell. Here, elderly mice underwent a new sort of gene therapy for six weeks. Afterward, their injuries healed, their heart health improved, and even their spines were straighter. The mice also lived longer, 30% longer.

Today, we target individual age-related diseases when they spring up. But this study could help us develop a therapy to attack aging itself, and perhaps even target it before it begins taking shape. But such a therapy is at least ten years away, according to Izpisua Belmonte.

Many biologists now believe that the body, specifically the telomeres—the structures at the end of chromosomes, after a certain time simply wear out. Once degradation overtakes us, it’s the beginning of the end. This study strengthens another theory. Over the course of a cell’s life, epigenetic changes occur. This is the activation or depression of certain genes in order to allow the organism to respond better to its environment. Methylation tags are added to activate genes. These changes build up over time, slowing us down, and making us vulnerable to disease.


Chromosomes with telomeres in red.

Though we may add life to years, don’t consider immortality an option, at least not in the near-term. “There are probably still limits that we will face in terms of complete reversal of aging,” Izpisua Belmonte said. “Our focus is not only extension of lifespan but most importantly health-span.” That means adding more healthy years to life, a noble prospect indeed.

The technique employs induced pluripotent stem cells (iPS). These are similar to those which are present in developing embryos. They are important as they can turn into any type of cell in the body. The technique was first used to turn back time on human skin cells, successfully.

By switching around four essential genes, all active inside the womb, scientists were able to turn skin cells into iPS cells. These four genes are known as Yamanaka factors. Scientists have been aware of their potential in anti-aging medicine for some time. In the next leg, researchers used genetically engineered mice who could have their Yamanaka factors manipulated easily, once they were exposed to a certain agent, present in their drinking water.

Since Yamanaka factors reset genes to where they were before regulators came and changed them, researchers believe this strengthens the notion that aging is an accumulation of epigenetic changes. What’s really exciting is that this procedure alters the epigenome itself, rather than having the change the genes of each individual cell.

The mechanics of epigenetics.

In another leg of the experiment, mice with progeria underwent this therapy. Progeria is a disease that causes accelerated aging. Those who have seen children who look like seniors know the condition. It leads to organ damage and early death. But after six months of treatment, the mice looked younger. They had better muscle tone and younger looking skin, and even lived around 30% longer than those who did not undergo the treatment.

Luckily for the mice, time was turned back the appropriate amount. If turned back too far, stem cells can proliferate in an uncontrolled fashion, which could lead to tumor formation. This is why researchers have been reticent to activate the Yamanaka factors directly. However, these scientists figured out that by intermittently stimulating the factors, they could reverse the aging process, without causing cancer. The next decade will concentrate on perfecting this technique.

Since the threat of cancer is great, terminally ill patients would be the first to take part in a human trial, most likely those with progeria. Unfortunately, the method used in this study could not directly be applied to a fully functioning human. But researchers believe a drug could do the job, and they are actively developing one.

“This study shows that aging is a very dynamic and plastic process, and therefore will be more amenable to therapeutic interventions than what we previously thought,” Izpisua Belmonte said. Of course, mouse systems and human one’s are far different. This only gives us an indication of whether or not it might work. And even if it does, scientists will have to figure out how far to turn back the clock. But as Izpisua Belmonte said, “With careful modulation, aging might be reversed.”

To learn more about anti-aging medicine, click here:

http://bigthink.com/philip-perry/scientists-are-one-step-closer-to-reversing-the-aging-process-entirely?utm_source=Big+Think+Weekly+Newsletter+Subscribers&utm_campaign=1da0cbaecc-WeeklyNewletter_122116&utm_medium=email&utm_term=0_6d098f42ff-1da0cbaecc-41172901

 

Ask Mick LaSalle (sfgate.com)

Dear Mick: Say there’s scale of belief, where would you fit in? Do you believe, on the one side, like Sartre, that the world is absurd, or on the other end, that everything is saturated with meaning, like Jung?
Kevin Steed, Oakland

Dear Kevin: I would say that everything is saturated with meaning, and though the meaning might be absurd, it’s still meaning, not anti-meaning, so that would place me with Jung. One of the things that fascinates me is the idea that everything in a cultural moment is related. It’s easy to see a connection, for instance, between, say, the Reagan era and “Rambo” and “Top Gun.” But those elements also might be related to things like big lapels on Armani suits, or drum machines in music. It seems that the farther we get from a period, the more we can see its elements as part of some larger vision, which, depending on how you see the world, you could call the mind of God, or the turning of the universe, or some mass consciousness coming into being. As for this particular cultural moment, the one we’re in, I’d try reading the mass consciousness, except I’m afraid I’d end up peeking through my fingers with both hands covering my face, like a modified Munch’s “The Scream.”

“Yes, Donald Trump’s America is full of idiots. But not in the way you think.”

The ancient Greek origins of an insult.

December 20 (WashingtonPost.com)

Nick Romeo is a critic and journalist based in Palo Alto, Calif.
 

Views from the Real World: Early Talks of G.I. Gurdjieff

First published in 1975, this book has established itself as an authentic source for those interested in Gurdjieff’s ideas and his approach to practical “work on oneself”.

About the author

George Gurdjieff was a modern magus who was born in Alexandropol, Armenia, and traveled widely as a young man, spending several years in Central Asia and Tibet. His experiences during this time led to his famous book Meetings with Remarkable Men, an account of his alleged encounters with Eastern spiritual teachers that was published posthumously in 1963. Gurdjieff’s system draws on diverse sources, including Sufism, Buddhism, and the Cabala. He taught that human beings have neither soul nor true will and must strive to cure these defects by work and suffering. The ordinary person is asleep, acting merely according to habit, and needs the shock of awakening. To this end he sponsored experiences of dance, exercise, hard labor, and sometimes surprises or acute frustration.  (Google Books)

Link:  https://www.google.com/search?q=Gurdjieff%2C+G.I.+(1976)+Views+from+the+Real+World.&ie=utf-8&oe=utf-8

Sunday Night Translation Group: December 18

Translation is a 5-step process using syllogistic reasoning to transform man and the universe back into Being. Being is the perfect, essential nature of all, and through the process of Translation, reality is uncovered and thus revealed. Through word tracking, getting to the essence of the words we use to express our current view of reality, we are uncovering essence, which is the only true reality.

Sense testimony:

Our lives are based on what we believe emotionally, not what we affirm intellectually.

Conclusions:

  1.  Life believes Itself emotionally, intelligently and affirmatively.
  2. Truth Consciousness I Am is Universally Instantaneously Self Evidently Agreeably Powerfully Abundantly Soundly moving all being choosing all there is, all I Am.
  3. I AM THAT I AM, Spirit’s Love of One Consciousness; the law of beingness is the discernment of Higher Mind.
  4. To come (see Comments).

Consciousness, sexuality, androgyny, futurism, space, the arts, science, astrology, democracy, humor, books, movies and more